mAb²: An antibody with inbuilt additional functions

• Overview
• Fcab™
• mAb²

mAb² antibodies are full IgG antibodies with two additional binding sites engineered into the CH3 domains. Depending on the type of additional binding sites assigned to the CH3 domains of the IgG molecule, a number of exciting and completely new therapeutic applications become possible. Examples include oligovalence (additional binding sites to the same disease antigen), dual targeting (additional binding sites to a second disease antigen, all within one single molecule) or tissue targeting (additional binding site to tissue-specific markers, transporting the antibody to the site of action). All these applications have one objective: making therapeutic antibodies even more effective in treating patients with high unmet medical need.

mAb² antibodies are normal antibodies with a second "pair of arms" capable of performing a therapeutically useful tasks. Modular Antibody Technology is absolutely unique in delivering such innovative therapeutic approaches of an antibody with only minimal changes in the molecular structure and production processes.