Scientific Approach

Publications

F-star develops novel bispecific antibodies to improve the treatment of serious diseases, with a focus on immuno-oncology.

IMG 4765 Resized

Katy L. Everett, Matthew Kraman, Francisca P.G. Wollerton, Carlo Zimarino, Katarzyna Kmiecik, Miguel Gaspar, Sarka Pechouckova, Natalie L. Allen, Jacqueline F. Doody, Mihriban Tuna (2018) - Generation of Fcabs targeting human and murine LAG-3 as building blocks for novel bispecific antibody therapeutics - Methods 150 (2019) 60-69

Wozniak-Knopp G., Stadlmayr G., Perthold JW., Stadlbauer K., Woisetschläger M., Sun H., Rüker F. (2017) Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments. Protein Engineering, Design and Selection

Tim D. Jones, Paul J. Carter, Andreas Plückthun, Max Vásquez, Robert G.E.Holgate, Isidro Hötzel, Andrew G. Popplewell, Paul W.H.I. Parren, Markus Enzelberger, Hendrik J. Rademaker, Michael R. Clark, David C. Lowe, Bassil I. Dahiyat, Victoria Smith, John M. Lambert, Herren Wu, Mary Reilly, John S.Haurum, Stefan Dübel, James S. Huston, Thomas Schirrmann, Richard A.J.Janssen, Martin Steegmaier, Jane A. Gross, Andrew R.M. Bradbury, Dennis R. Burton, Dimiter S. Dimitrov, Kerry A. Chester, Martin J. Glennie, Julian Davies, Adam Walker, Steve Martin, John McCafferty & Matthew P. Baker (2015) – The The INNs and outs of antibody non-proprietary names. mAbs 1-9 Nov.1.

Nature Biopharma Dealmarkers, 2 November 2015: Transformative bispecific antibody technology.

Leung, K., Batey, S., Rowlands, R., Isaac, S.J., Jones, P., Drewett, V., Carvalho, J., Gaspar, M., Weller, S., Medcalf, M., Wydro, M.M., Pegram, R., Mudde, G.C., Bauer, A., Moulder, K., Woisetschläger, M., Tuna, M., Haurum, J.S., Sun, S. (2015) A HER2-specific modified Fc fragment (Fcab) induces anti-tumour effects through degradation of HER2 and apoptosis. Mol. Ther. 23 (10).

Kainer, M., Antes, B., Wiederkum, S., Wozniak-Knopp, G., Bauer, A., Rüker, F., Woisetschläger, M. (2012) Correlation between CD16a binding and immuno effector functionality of an antigen specific immunoglobulin Fc fragment (Fcab). Arch. Biochem. Biophys. 526, 154-158.

Woisetschläger, M., Antes, B., Borrowdale, R., Wiederkum, S., Kainer, M., Steinkellner, H., Wozniak-Knopp, G., Moulder, K., Rüker, F., Mudde, G.C., (2013) Functional in vitro and in vivo characterization of an immunoglobulin Fc fragment with engineered Her-2/neu binding sites.

Matthew Kraman, Katarzyna Kmiecik, Carlo Zimarino, Mustapha Faroudi, Katy Everett, Mateusz Wydro, Jacqueline Doody (2016) - A LAG-3/PD-L1 bispecific antibody inhibits tumour growth in two syngeneic colon carcinoma models.
Poster at the annual SITC (Society for Immunotherapy of Cancer) 2016 meeting, National Harbor, Maryland, USA