Bibliography
For those who wish to find out more about F-star’s technology and the published work in this field, the following publications may be of interest:
Rüker, F., Wozniak-Knopp, G. (2009): Engineering of Non-CDR Loops in Immunoglobulin Domains. In: Little, M. (Ed.), Recombinant Antibodies for Immunotherapy Part VI, 231-242; Cambridge University Press, New York; ISBN 978-0-521-88732-8
Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, and Rüker F. Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu binding sites and antibody properties. Protein Eng Des Sel. 23(4):289-97 (2010).
Woisetschläger M, Rüker F, Mudde GC, Wozniak-Knopp G, Bauer A and Himmler G. Modular Antibody Engineering: antigen binding immunoglobulin Fc CH3 domains as building blocks for bi-specific antibodies (mAb²), in: Fusion protein technologies for biopharmaceuticals: Applications and Challenges. (in press)